Where is mhc class 1

Tapasin and other chaperones: models of the MHC class I loading complex. Biol Chem — Immunity — A single polymorphic residue within the peptide-binding cleft of MHC class I molecules determines spectrum of tapasin dependence.

J Immunol —8. Tapasin is a facilitator, not an editor, of class I MHC peptide binding. Tapasin dependence of major histocompatibility complex class I molecules correlates with their conformational flexibility.

F pocket flexibility influences the tapasin dependence of two differentially disease-associated MHC class I proteins. Eur J Immunol — Lewis JW, Elliott T. Evidence for successive peptide binding and quality control stages during MHC class I assembly.

Curr Biol — PubMed Abstract Google Scholar. Tapasin decreases immune responsiveness to a model tumor antigen. J Clin Immunol — Chen M, Bouvier M. EMBO J — The cell biology of major histocompatibility complex class I assembly: towards a molecular understanding. Tissue Antigens — Mol Immunol — Molecular mechanism of peptide editing in the tapasin-MHC I complex. Sci Rep Roche PA, Cresswell P. Cell — Nat Struct Mol Biol —8. Trends Immunol —7. Mechanistic basis for epitope proofreading in the peptide-loading complex.

Tapasin edits peptides on MHC class I molecules by accelerating peptide exchange. A mechanistic basis for the co-evolution of chicken tapasin and major histocompatibility complex class I MHC I proteins.

J Biol Chem — Nat Struct Biol — Biochemistry — J Mol Biol — A conformational change in the human major histocompatibility complex protein HLA-DR1 induced by peptide binding. Recognition of open conformers of classical MHC by chaperones and monoclonal antibodies.

Immunol Rev — MHC class II complexes sample intermediate states along the peptide exchange pathway. Nat Commun Conformational variation in structures of classical and non-classical MHCII proteins and functional implications. Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle.

Structural analysis of MHC class I molecules with bound peptide antigens. Semin Immunol — A subset of HLA-B27 molecules contains peptides much longer than nonamers. High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I.

Implications for T-cell receptor engagement and T-cell immunodominance. J Biol Chem —9. Haematologica —8. Peptide linkage to the alpha-subunit of MHCII creates a stably inverted antigen presentation complex. A novel pathway of presentation by class II-MHC molecules involving peptides or denatured proteins important in autoimmunity. Mol Immunol —8. Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register.

Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion. J Exp Med — Zhou Z, Jensen PE. Front Immunol Susceptibility to HLA-DM protein is determined by a dynamic conformation of major histocompatibility complex class II molecule bound with peptide. Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.

Nat Genet —6. Molecular mechanisms for contribution of MHC molecules to autoimmune diseases. Stability of empty and peptide-loaded class II major histocompatibility complex molecules at neutral and endosomal pH: comparison to class I proteins. Comparative molecular dynamics analysis of tapasin-dependent and -independent MHC class I alleles.

Protein Sci — Differential tapasin dependence of MHC class I molecules correlates with conformational changes upon peptide dissociation: a molecular dynamics simulation study.

Dynamical characterization of two differentially disease associated MHC class I proteins in complex with viral and self-peptides. Two polymorphisms facilitate differences in plasticity between two chicken major histocompatibility complex class I proteins. PLoS One 9:e Selector function of MHC I molecules is determined by protein plasticity.

The peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics. J Immunol —9. Not all empty MHC class I molecules are molten globules: tryptophan fluorescence reveals a two-step mechanism of thermal denaturation. Thermal stability comparison of purified empty and peptide-filled forms of a class I MHC molecule.

Structural and functional mosaic nature of MHC class I molecules in their peptide-free form. Mol Immunol —9. Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro. Cell —7. The crystal structure of H-2D b complexed with a partial peptide epitope suggests a major histocompatibility complex class I assembly intermediate.

Peptide-independent stabilization of MHC class I molecules breaches cellular quality control. J Cell Sci — Stable peptide binding to MHC class II molecule is rapid and is determined by a receptive conformation shaped by prior association with low affinity peptides.

J Immunol —6. Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association. Empty and peptide-loaded class II major histocompatibility complex proteins produced by expression in Escherichia coli and folding in vitro. Protein Expr Purif — Probing the ligand-induced conformational change in HLA-DR1 by selective chemical modification and mass spectrometric mapping.

Small organic compounds enhance antigen loading of class II major histocompatibility complex proteins by targeting the polymorphic P1 pocket. PLoS One 3:e Characterization of structural features controlling the receptiveness of empty class II MHC molecules. PLoS One 6:e Flexibility of the MHC class II peptide binding cleft in the bound, partially filled, and empty states: a molecular dynamics simulation study.

Biopolymers — Monoclonal antibodies specific for the empty conformation of HLA-DR1 reveal aspects of the conformational change associated with peptide binding. Differential peptide dynamics is linked to major histocompatibility complex polymorphism. HLA-B27 subtypes differentially associated with disease exhibit conformational differences in solution. How T cell receptors interact with peptide-MHCs: a multiple steered molecular dynamics study. Proteins — PLoS Comput Biol 8:e PLoS One 7:e Proline substitution independently enhances H-2D b complex stabilization and TCR recognition of melanoma-associated peptides.

Chem Pharm Bull Tokyo — A comparative approach linking molecular dynamics of altered peptide ligands and MHC with in vivo immune responses. PLoS One 5:e Association of HLA-DR1 with the allergic response to the major mugwort pollen allergen: molecular background.

BMC Immunol Bello M, Correa-Basurto J. Molecular dynamics simulations to provide insights into epitopes coupled to the soluble and membrane-bound MHC-II complexes. PLoS One 8:e Chem Pharm Bull Tokyo —8. Dynamic influence of the two membrane-proximal immunoglobulin-like domains upon the peptide-binding platform domain in class I and class II major histocompatibility complexes: normal mode analysis. Chem Pharm Bull Tokyo —9. Influence of inflammation-related changes on conformational characteristics of HLA-B27 subtypes as detected by IR spectroscopy.

FEBS J — J Biomol NMR — Dynamics of free versus complexed beta2-microglobulin and the evolution of interfaces in MHC class I molecules. In situ analysis of the antigen-processing machinery in acute myeloid leukaemic blasts by tissue microarray. Defects in the human leukocyte antigen class I antigen processing machinery in head and neck squamous cell carcinoma: association with clinical outcome.

Clin Cancer Res. HLA class I antigen down-regulation in primary laryngeal squamous cell carcinoma lesions as a poor prognostic marker. Down-regulation of HLA class I antigen-processing machinery components in esophageal squamous cell carcinomas: association with disease progression. Scand J Gastroenterol. Methylation of the promoter of human leukocyte antigen class I in human esophageal squamous cell carcinoma and its histopathological characteristics.

J Thorac Cardiovasc Surg. Association of defective HLA-I expression with antigen processing machinery and their association with clinicopathological characteristics in Kazak patients with esophageal cancer.

Chin Med J Engl. Characterization of the immune escape phenotype of human gastric cancers with and without high-frequency microsatellite instability. J Pathol.

MHC class I antigen processing pathway defects, ras mutations and disease stage in colorectal carcinoma. Int J Cancer. BMC Cancer. Down-regulation of HLA class I antigen processing molecules: an immune escape mechanism of renal cell carcinoma?

J Urol. Characterization of human lymphocyte antigen class I antigen-processing machinery defects in renal cell carcinoma lesions with special emphasis on transporter-associated with antigen-processing down-regulation. Association of HLA class I antigen abnormalities with disease progression and early recurrence in prostate cancer. PLoS One. Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma.

Int J Oncol. Expression of antigen processing and presenting molecules in brain metastasis of breast cancer. WHO grade associated downregulation of MHC class I antigen-processing machinery components in human astrocytomas: does it reflect a potential immune escape mechanism?

Acta Neuropathol. Multiple defects of the antigen-processing machinery components in human neuroblastoma: immunotherapeutic implications. Down-regulation of HLA class I antigen-processing molecules in malignant melanoma: association with disease progression. Am J Pathol. TAP1 down-regulation in primary melanoma lesions: an independent marker of poor prognosis. Genetic variation of antigen processing machinery components and association with cervical carcinoma.

Genes Chromosomes Cancer. HLA class I antigen and transporter associated with antigen processing downregulation in metastatic lesions of head and neck squamous cell carcinoma as a marker of poor prognosis. Oncol Rep. HLA class I expression and chromosomal deletions at 6p and 15q in head and neck squamous cell carcinomas. Tissue Antigens. Role of antigen-processing machinery in the in vitro resistance of squamous cell carcinoma of the head and neck cells to recognition by CTL.

Loss of expression of antigen-presenting molecules in human pancreatic cancer and pancreatic cancer cell lines. Clin Exp Immunol. Loss of major histocompatibility complex-encoded transporter associated with antigen presentation TAP in colorectal cancer. Down-regulation of the antigen processing machinery is linked to a loss of inflammatory response in colorectal cancer.

Hum Pathol. TAP expression provides a general method for improving the recognition of malignant cells in vivo. Nat Biotechnol. Loss of transporter in antigen processing 1 transport protein and major histocompatibility complex class I molecules in metastatic versus primary breast cancer. Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas. Mutations in TAP genes are common in cervical carcinomas.

Deficient expression of components of the MHC class I antigen processing machinery in human cervical carcinoma. Association of TAP1 downregulation in human primary melanoma lesions with lack of spontaneous regression. Melanoma Res. Immune escape of melanoma: first evidence of structural alterations in two distinct components of the MHC class I antigen processing pathway.

Human leukocyte antigen and antigen processing machinery component defects in astrocytic tumors. Induction of transporter associated with antigen processing by interferon gamma confers endothelial cell cytoprotection against natural killer-mediated lysis.

Interferon-gamma rapidly increases peptide transporter TAP subunit expression and peptide transport capacity in endothelial cells. Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma.

Nat Genet. J Cell Physiol. Distinct molecular mechanisms leading to deficient expression of ER-resident aminopeptidases in melanoma. Association of tapasin and HLA class I antigen down-regulation in primary maxillary sinus squamous cell carcinoma lesions with reduced survival of patients.

Downregulation of the constitutive tapasin expression in human tumor cells of distinct origin and its transcriptional upregulation by cytokines. Downregulation of tapasin expression in primary human oral squamous cell carcinoma: association with clinical outcome. Tumour Biol. HLA class I antigen processing machinery component expression and intratumoral T-Cell infiltrate as independent prognostic markers in ovarian carcinoma. Expression and prognostic significance of prothymosin-alpha and ERp57 in human gastric cancer.

Identification of E2F1 as an important transcription factor for the regulation of tapasin expression. Soluble HLA in human body fluids. Hum Immunol. Serum HLA class I antigens: markers and modulators of an immune response? Immunol Today. Soluble HLA antigens: new roles and uses. Tabayoyong WB Zavazava N. Soluble HLA revisited. Leuk Res. Krangel MS. Soluble beta 2-microglobulin-free class I heavy chains are released from the surface of activated and leukemia cells by a metalloprotease.

Demaria S Bushkin Y. Soluble HLA proteins with bound peptides are released from the cell surface by the membrane metalloproteinase. Bangia N Ferrone S. Antigen presentation machinery APM modulation and soluble HLA molecules in the tumor microenvironment: do they provide tumor cells with escape mechanisms from recognition by cytotoxic T lymphocytes?

Immunol Invest. Biochemical complexity of serum HLA class I molecules. Increased serum levels of beta2m-free HLA class I heavy chain in multiple myeloma. Br J Haematol. Size variants of betamicroglobulin-free human leucocyte antigen class I heavy chain make different contributions to its serum increase in multiple myeloma.

Analysis of HLA expression in human tumor tissues. Garrido F Algarra I. MHC antigens and tumor escape from immune surveillance. Adv Cancer Res. Selection for beta 2-microglobulin mutation in mismatch repair-defective colorectal carcinomas. High frequency of altered HLA class I phenotypes in invasive colorectal carcinomas. Analysis of HLA class I alterations in tumors: choosing a strategy based on known patterns of underlying molecular mechanisms. Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features.

Constitutive transduction of peptide transporter and HLA genes restores antigen processing function and cytotoxic T cell-mediated immune recognition of human melanoma cells. Downregulation of HLA class I molecules in primary oral squamous cell carcinomas and cell lines.

Arch Med Res. Multiple mechanisms generate HLA class I altered phenotypes in laryngeal carcinomas: high frequency of HLA haplotype loss associated with loss of heterozygosity in chromosome region 6p High frequency of altered HLA class I phenotypes in invasive breast carcinomas.

Implications for immunosurveillance of altered HLA class I phenotypes in human tumours. Locus-specific transcriptional control of HLA genes. Regulation of the expression of major histocompatibility complex class I genes in human colorectal cancer. Cancer Detect Prev. High frequency of altered HLA class I phenotypes in laryngeal carcinomas. HLA-B locus-specific downregulation in human melanoma requires enhancer A as well as a sequence element located downstream of the transcription initiation site.

C-myc represses transiently transfected HLA class I promoter sequences not locus-specifically. Down-regulation of the MHC class I antigen-processing machinery after oncogenic transformation of murine fibroblasts.

Differential expression of tapasin and immunoproteasome subunits in adenovirus type 5- versus type transformed cells. Seliger B. Microsatellite analysis of microdissected tumor cells and 6p high density microsatellite analysis in head and neck squamous cell carcinomas with down-regulated human leukocyte antigen class I expression.

Lab Invest. Loss of an HLA haplotype in pancreas cancer tissue and its corresponding tumor derived cell line. Quantification of serum-soluble HLA class I antigens in patients with gastric cancer. Soluble HLA class I antigens in plasma of patients with malignant melanoma. Anticancer Res. Clinical significance of soluble form of HLA class I molecule in Japanese patients with pancreatic cancer. The biochemistry and cell biology of antigen processing and presentation.

Annu Rev Immunol. Cerundolo V de la SH. Semin Immunol. Bare lymphocyte syndrome: an opportunity to discover our immune system. Immunol Lett. TAP deficiency syndrome. Activity and phenotype of natural killer cells in peptide transporter TAP -deficient patients type I bare lymphocyte syndrome. Processing and presentation of tumor antigens and vaccination strategies.

Campoli M Ferrone S. Int Immunol. Zavazava N Kronke M. Nat Med. Antigen-specific blockade of T cells in vivo using dimeric MHC peptide. Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia.

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Proteasomes and Immunoproteasomes: Structure, Components, and Functions. Conclusions and Perspectives. Patrizia Leone , Patrizia Leone. Oxford Academic. Eui-Cheol Shin. Federico Perosa. Angelo Vacca. Franco Dammacco. Vito Racanelli. Revision received:.

Select Format Select format. Permissions Icon Permissions. Open in new tab Download slide. Table 1. ABC proteins in antigen translocation and viral inhibition.

Nature Chem. Blanchard, N. Endoplasmic reticulum aminopeptidase associated with antigen processing defines the composition and structure of MHC class I peptide repertoire in normal and virus-infected cells.

Serwold, T. Saveanu, L. Nature Immunol. Saric, T. York, I. Roelse, J. Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling. Neijssen, J. Cross-presentation by intercellular peptide transfer through gap junctions.

Nature , 83—88 Pang, B. Direct antigen presentation and gap junction mediated cross-presentation during apoptosis. Saccheri, F. Bacteria-induced gap junctions in tumors favor antigen cross-presentation and antitumor immunity. This study shows that gap junctions are induced by S.

Typhimurium infection and are essential for generating a strong antitumour response with a S. Typhimurium-based antitumour vaccine. Trowsdale, J. HLA genomics in the third millennium. Neisig, A. Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing. Peh, C. Immunity 8 , — Leslie, A. Malik, P. Herberts, C. Cutting edge: HLA-B27 acquires many N-terminal dibasic peptides: coupling cytosolic peptide stability to antigen presentation.

Evans, D. Nature Genet. Princiotta, M. Quantitating protein synthesis, degradation, and endogenous antigen processing. Immunity 18 , — Making sense of mass destruction: quantitating MHC class I antigen presentation. Immunity 20 , — Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation.

Kloetzel, P. Kessler, J. Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes. Kawahara, M. Complexity, contradictions, and conundrums: studying post-proteasomal proteolysis in HLA class I antigen presentation.

Lev, A. The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation. Immunity 28 , — Compartmentalized MHC class I antigen processing enhances immunosurveillance by circumventing the law of mass action. Hessa, T. Protein targeting and degradation are coupled for elimination of mislocalized proteins. Tenzer, S. Lundegaard, C. Major histocompatibility complex class I binding predictions as a tool in epitope discovery.

Immunology , — Martayan, A. Gromme, M. Recycling MHC class I molecules and endosomal peptide loading. USA 96 , — Rocca, A. The fate of the three subunits of major histocompatibility complex class I molecules. Boname, J. Efficient internalization of MHC I requires lysine and lysine mixed linkage polyubiquitin chains. Traffic 11 , — Bartee, E. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins.

Howe, C. Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules. Fernando, M. Defining the role of the MHC in autoimmunity: a review and pooled analysis. PLoS Genet. Anders, A.

Denzin, L. Right place, right time, right peptide: DO keeps DM focused. Romieu-Mourez, R. Geppert, T. Bland, P.

MHC class II expression by the gut epithelium. Today 9 , — Koretz, K. Metachromasia of 3-aminoethylcarbazole AEC and its prevention in immunoperoxidase techniques. Histochemistry 86 , — Mulder, D. Antigen presentation and MHC class II expression by human esophageal epithelial cells: role in eosinophilic esophagitis. Schonefuss, A.

Upregulation of cathepsin S in psoriatic keratinocytes. Tjernlund, U. Anti-Ia-reactive cells in mycosis fungoides: a study of skin biopsies, single epidermal cells and circulating T lymphocytes. Acta Derm. Choi, N. Regulation of major histocompatibility complex class II genes. Muhlethaler-Mottet, A. Reith, W. Smith, M. Sisk, T. Phosphorylation of class II transactivator regulates its interaction ability and transactivation function.

Greer, S. Bhat, K. Phosphorylation and ubiquitination of degron proximal residues are essential for class II transactivator CIITA transactivation and major histocompatibility class II expression. Paul, P. Many unknown factors are identified and additional screens are presented to reveal new pathways controlling MHC class II expression and transport in immature DCs. Busch, R. Bertolino, P. Landsverk, O. MHC II and the endocytic pathway: regulation by invariant chain.

Bodmer, H. Viville, S. Cell 72 , — Bikoff, E. Tewari, M. Hofmann, M. The leucine-based sorting motifs in the cytoplasmic domain of the invariant chain are recognized by the clathrin adaptors AP1 and AP2 and their medium chains. Dugast, M. McCormick, P. Santambrogio, L. Involvement of caspase-cleaved and intact adaptor protein 1 complex in endosomal remodeling in maturing dendritic cells.

Peters, P. Sanderson, F. Kropshofer, H. Engering, A. Association of distinct tetraspanins with MHC class II molecules at different subcellular locations in human immature dendritic cells.